Combivir Lamivudine/Zidovudine and/or alternatives

Product / Manufacturer
Quantity / Price (USD)

Combivir 150/300mg

Manufacturer: Glaxo Smithkline Source Country : Turkey
Shipped from : Turkey

  • This item requires a prescription from your doctor

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  • Please note that the source country, shipping country and/or manufacture may vary depending on availability.

Description of Combivir

Combivir has two NRTIs or nucleoside reverse transcriptase inhibitors as its active ingredients: Zidovudine and Lamivudine. You can buy Combivir in the form of oral tablets.

Indications & Dosage of Combivir

Combivir is used to control HIV infection. In some cases, it is also used to prevent infection in patients who have come in contact with the HIV virus. The drug works by decreasing the amount of HIV viruses in the patient’s body, so that his or her immunity can improve. It also reduces the risk of developing HIV related complications such as cancer and new infections.

You must remember that Combivir is used only for controlling HIV. It cannot cure the disease. It can also not prevent the spread of the virus to others through blood contamination or sexual contact.

If you are an adult and weigh more than 30 kgs, your doctor will advise you to take one Combivir 150/300mg tablet twice a day. This medicine should not be given to patients less than 30 kgs. You can take the tablet with or without meals.

Side Effects & Interactions of Combivir

Combivir can commonly lead to mild side effects including:

  • Changes in location and shape of body fat, especially in the legs, arms, face, trunk, breasts and neck
  • Mild nausea, diarrhea or vomiting
  • Tingling or numbness
  • Sleeping problems
  • Dizziness, tiredness or headache
  • Cough, stuffy or runny nose

Some serious side effects associated with Combivir include:

  • Fever, body ache, chills, flu symptoms
  • Pale skin, unusual weakness, easy bruising and bleeding
  • Trouble standing, climbing stairs, or swallowing
  • Liver problems, identified by loss of appetite, stomach pain, clay-colored stools, dark urine and yellowing of the eyes or skin
  • Sores or white patches inside the mouth or on the lips
  • Pancreatitis, identified by nausea, vomiting, severe pain in the upper stomach, or fast heart rate

In some cases, Combivir can also lead to a serious condition known as lactic acidosis. Symptoms of such a condition include:

  • Muscle weakness or pain
  • Cold or numb feeling in the legs or arms
  • Difficulty breathing
  • Dizziness, weakness, tiredness or lightheadedness
  • Stomach pain, vomiting, nausea
  • Uneven or slow heart rate

Some of the drugs that may interact with Combivir include ribavirin, interferon alfa, stavudine, probenecid, zalcitabine, medicines that reduce blood cell count or bone marrow function (e.g. ganciclovir or trimethoprim) or drugs that affect the kidneys (e.g. NSAIDs like naproxen or ibuprofen).

Some medicines may affect the removal of Zidovudine from the patient’s body. Such drugs include rifampin, fluconazole and valproic acid. If you are taking clarithromycin along with Combivir, you should keep a gap of at least 2 hours between them.

Warnings & Precautions of Combivir

Before you buy Combivir, inform your doctor if you have a kidney or liver disease, pancreatitis, low white or red blood cell count, or an alcohol addiction. You should avoid alcohol intake during Combivir treatment, as it may increase your risk of developing pancreatitis or a liver problem.

Children may be more prone to pancreatitis due to Combivir use. Therefore, this medicine is usually not recommended to be used by pediatric patients.

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