Depen Penicillamine and/or alternatives

Product / Manufacturer
Quantity / Price (USD)

Depen 125mg

Marketed as D-Penamine in Australia Manufacturer: Viatris Pty Ltd Source Country : Australia
Shipped from : Australia

Depen 250mg

Marketed as D-Penamine in Australia Manufacturer: Viatris Pty Ltd Source Country : Australia
Shipped from : Australia

Penicillamine 125mg

Generic Alternative to Depen 125mg
Manufacturer: A UK MHRA approved Generic Manufacturer Source Country : United Kingdom
Shipped from : United Kingdom

Penicillamine 250mg

Generic Alternative to Depen 250mg
Manufacturer: A UK MHRA approved Generic Manufacturer Source Country : United Kingdom
Shipped from : United Kingdom
  • What is a Generic?

  • This item requires a prescription from your doctor

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  • Please note that the source country, shipping country and/or manufacture may vary depending on availability.

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Description of Depen

Depen is a chelating agent. It helps in removing other chemicals from our body by attaching itself to them. The drug removes access copper associated with Wilson’s disease. It also reduces cysteine in the urine to treat severe rheumatoid arthritis. Its generic name is Penicillamine.

Penicillamine combines with copper and other chemicals’ molecules, making them more soluble. In this way, they are excreted from the body through urine. The drug is administered as oral tablets. Depen is available in a strength of Depen 250mg.

The inactive ingredients present in Depen are: hypromellose povidone, edetate disodium, magnesium trisilicate, polyethylene glycol, starch, lactose, simethicone emulsion, and stearic acid.

Indications & Dosage of Depen

For Wilson’s Disease, it is recommended that a doctor decide the optimal dosage after determining copper levels in the patient’s body. A dose of 250mg that results in an initial 24-hour cupriuresis of over 2 mg should be continued for about three months and increased gradually.

For Cystine, the usual dosage of Penicillamine recommended is 2g/day for adults, with a range of 1 to 4 g/day. The dose must be individualized to an excretion of 100-200mg of copper per day.

Dosages more than 500mg should be given in divided doses. Depen must be taken on an empty stomach at least 1 hour before or 2 hours after the meal, as taking it with anything else decreases it effects. Store Depen at controlled room temperature of about 20°-25°C

Side Effects & Interactions of Depen

Before you buy Depen, tell your doctor if you are allergic to any of its ingredients, if you have kidney disease or any other serious illness. Depen may cause birth defects in unborn babies. Do not take this medicine without consulting your doctor in case of a pregnancy.

The less serious side effects of using this drug are :

  • Nausea, vomiting, diarrhea, or decreased appetite
  • Itching or a rash
  • Ringing in the ears
  • Sores in the mouth
  • Decreased taste
  • Poor wound healing
  • Increased wrinkling of the skin

The serious side effects are:

  • Allergic reaction
  • Sore throat
  • Abdominal pain
  • Yellow skin or eyes
  • Unusual bleeding or bruising
  • Fever or chills
  • Muscle weakness
  • Blood in the urine
  • Double vision
  • Unexplained shortness of breath, wheezing or coughing

Various drugs interacting with Depen are:

  • Auranofin
  • Aurothioglucose
  • Solganal
  • Sodium Thiomalate
  • Myochrysine
  • Aurolate
  • Quinine
  • Mefloquine
  • Lariam
  • Chloroquine
  • Aralen
  • Hydroxychloroquine
  • Plaquenil
  • Primaquine
  • Pyrimethamine
  • Daraprim
  • Phenylbutazone

Warnings & Precautions of Depen

Do not take any medicines, OTC or supplements within 1 hour of taking Depen. Many drugs such as antacids, vitamins and supplements can decrease the effect of Penicillamine. Before you buy Depen, make sure to talk to your doctor about all the allergies and diseases you have.

IMPORTANT DISCLAIMER: All medical content is supplied by a third party company who is independent from this web site. As such, this web site can not guarantee the reliability, accuracy, and /or medical efficacy of the information provided. In all circumstances, you should seek the advice of a health professional pertaining to drug, treatment and/or medical condition advice. Note that not all products are shipped by our contracted Canadian pharmacy. This website contracts with dispensaries around the world that ship products directly to our customers. Some of the jurisdiction include but are not limited to United Kingdom, Europe, Turkey, India, Canada, Vanuatu, Mauritius, and USA. The items within your order may be shipped from any one of these jurisdiction depending on the availability and cost of the products at the time you place your order. The products are sourced from these countries as well as others. Please note that the product appearance may vary from actual product received depending on availability. The content above has been supplied by a third party who is contracted to, and also independent from, this web site. This web site cannot guarantee the accuracy, reliability or medical efficacy of the content provided. It is suggested that you always seek the advice of a health professional for treatment, drug or medical condition advice.

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