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Create an account Zofran Injection Ondansetron Hydrochloride and/or alternatives
Ondansetron Hydrochloride 2mg/mL
Generic Alternative to Zofran Injection 2mg/mLMarketed as Emeset Injection in India Manufacturer: Cipla Source Country : India
Shipped from : India
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This item requires a prescription from your doctor
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Description of Zofran Injection
Ondansetron hydrochloride is the generic name of Zofran Injection, and it is administered intravenously. Ondansetron hydrochloride is considered to be a selective blocking agent of the 5-HT3 serotonin receptor. It is available in the form of an off-white powder form and is soluble in water. Each single dose 2 mL vial of Zofran Injection contains ondansetron 2 mg as the hydrochloride dihydrate, sodium citrate dihydrate 0.25 mg, sodium chloride 9 mg, and citric acid monohydrate 0.5 mg. The solution for the injection has a pH value of 3.3 to 4.0. You can buy Zofran Injection only if it has been prescribed by your doctor.
Indications & Dosage of Zofran Injection
Zofran Injection is prescribed for intravenous administration to prevent vomiting and nausea in patients undergoing emetogenic cancer chemotherapy courses. This injection is approved for administration in patients over 6 months of age.
Prior to administration, the vial containing Zofran must be diluted to form an injectable solution. The recommended dose for adults is a single Zofran Injection 32 mg dose or three doses of Zofran Injection 0.15-mg/kg. If a 32 mg dose is being administered, it should be infused for over 15 minutes and should be given to the patient 30 minutes prior to the emetogenic chemotherapy course. The recommended dose for pediatric patients in the age group of 6 months to 18 years is three Zofran Injection 0.15-mg/kg doses. The first dose should be administered 30 minutes prior to the emetogenic chemotherapy course, and subsequent doses should be administered between 4 and 8 hours from the time of the first dose.
Side Effects & Interactions of Zofran Injection
Zofran Injection can lead to mild or moderate side effects such as:
- Electrocardiographic alterations
- Upset stomach and diarrhea
- Angina or chest pain
- Mild to severe headache
- Symptoms of fever
- Constipation
- Skin rashes, especially near the injected site
- Extrapyramidal reactions
- Hypokalemia
- Drowsiness and sedation
There are some adverse effects of Zofran Injection that may require immediate medical intervention. These include:
- Cold sensation and numbness
- Pruritus
- Paresthesia
- Ventricular and supraventricular tachycardia
- Premature ventricular contraction
- Atrial fibrillation
- Second-degree heart block
- QT/QTc interval prolongation
- ST segment depression
- Syncope
- Laryngeal edema
- Laryngospasm
Zofran Injection is known to interact with certain drugs like amiodarone, dolasetron, bepridil, sotalol, apomorphine, arsenic trioxide, quinidine, vandetanib, citalopram, cisapride, ibutilide, crizotinib, iloperidone, haloperidol, halofantrine, and nilotinib.
Warnings & Precautions of Zofran Injection
Although there is no controlled data available to confirm the reaction of Ondansetron Solution in pregnant women, most doctors believe that it causes fetal damage. Therefore, you must consult your doctor before you buy Zofran Injection if you are pregnant. It is also not known if Ondansetron Solution is secreted into breast milk, but administration is not recommended during breastfeeding. Necessary precautions and consultations with the doctor are necessary if Zofran Injection has to be administered to children below the age of 4 years.
You need to discuss your medical history with the doctor prior to using Zofran Injection. Inform him/her if you have undergone surgery or if you:
- Are allergic to ondansetron solution
- Have recently undergone or are undergoing abdominal surgery
- Are suffering from severe hepatic impairment
- Are suffering from severe renal impairment
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