Sinemet CR Levodopa/Carbidopa CR and/or alternatives

Product / Manufacturer
Quantity / Price (USD)

Sinemet CR 100/25mg

Marketed as Half Sinemet CR in European Union Manufacturer: Merck Sharp & Dohme Ltd Source Country : United Kingdom
Shipped from : United Kingdom

Sinemet CR 200/50mg

Manufacturer: Merck Source Country : New Zealand

This product is currently unavailable.

Levodopa/Carbidopa CR 100/25mg

Generic Alternative to Sinemet CR 100/25mg
Marketed as Syndopa CR 125 in India Manufacturer: Sun Pharma Source Country : India
Shipped from : India

Levodopa/Carbidopa CR 200/50mg

Generic Alternative to Sinemet CR 200/50mg
Marketed as Syndopa CR in India Manufacturer: Sun Pharma Source Country : India
Shipped from : India
  • What is a Generic?

  • This item requires a prescription from your doctor

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Description of Sinemet CR

Sinemet CR is a combination drug containing two active ingredients- levodopa and carbidopa. Levodopa is an aromatic amino acid which metabolises into dopamine in the brain. Patients who have Parkinson’s disease need an increase in dopamine levels for the symptomatic treatment of this disorder. The neurotransmitter (dopamine), however, affects a patient adversely if released in other body parts. Carbidopa, being an inhibitor of aromatic amino acid enzymes, does not allow the metabolism of Levodopa in the body (it cannot cross the brain-blood barrier) and as such, reduces the chances of negative reactions. Each tablet of Sinemet CR tablet contains 1 part carbidopa and 4 parts levodopa.

Patients can buy Sinemet CR either as 50mg-200mg or as 25mg-100mg sustained release tablets.

The generic name of Sinemet CR is Carbidopa/Levodopa, and this medicine belongs to the group of dopaminergic agents.

Indications & Dosage of Sinemet CR

Sinemet CR is indicated in the treatment of idiopathic Parkinson’s disease or symptoms similar to or associated with Parkinson’s disease caused due to an injured nervous system.

Patients who buy Sinemet CR need to be in constant consultation with their doctors regarding dosage initiation, adjustments and maintenance. The administration of this drug follows a strict titration process.

Sinemet CR sustained release tablets should not be crushed, chewed, broken or dissolved while ingesting them. It is necessary that the tablets be swallowed whole to ensure an even and regulated supply of dopamine in the brain. There should be a minimum time gap of 4 to 6 hours between two consecutive doses.

This medication may be stored at any temperature between 15 and 30 degrees Celsius, though 25 degrees is the optimum temperature.

Side Effects & Interactions of Sinemet CR

Even though the presence of carbidopa in Sinemet CR reduces the chances of major side effects of levodopa, patients using this drug may still experience some adverse effects. Some of the minor side effects of Sinemet CR are listed below. These generally do not require medical attention and disappear after a while in most cases.

  • Headache
  • Nausea
  • Vomiting
  • Dark color saliva, urine, sweat
  • Insomnia

There, however, may be instances of some serious side effects of this drug that require medical guidance, dosage adjustments or preventive medications. Patients should notify their doctors immediately if any of the following side effects of Sinemet CR are observed:

  • Irregularities in heartbeat/ heart rate
  • Increased twitching or blinking of the eyes
  • Fainting
  • Spasms, seizures
  • Mood changes like depression, anxiety, confusion
  • Easy bruising and bleeding
  • Fever, sore throat, flu like symptoms or other symptoms of infection
  • Vision changes
  • Tarry/black stool
  • Prolonged erection
  • Shallow breathing, chest pain
  • Tingling or numbness in the limbs

Sinemet CR is known to interact with quite a large number of drugs and it is important that patients disclose the current list of medications they are on to their doctors. Drugs that interact with Sinemet CR include: tetrabenazine, MAO inhibitors, hypertension medications, antidepressants, antipsychotic drugs, tryptophan and other medications used to treat Parkinson’s disease.

Warnings & Precautions of Sinemet CR

Patients who are allergic to any ingredient in Sinemet CR, are below 18 years of age, have narrow angle glaucoma, skin cancer (or a history of) and have used an MAO inhibitor in the preceding fortnight should not use this drug.

Sinemet CR causes drowsiness. Patients should avoid alcohol and drugs that have a similar effect while using this medicine.

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