Glucovance (Glyburide/Metformin) and/or equivalents

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Description of Glucovance

Glucovance is a combination medication that contains two drugs with the generic names, Metformin Hydrochloride and Glibenclamide. Metformin belongs to a group of medicines known as biguanides while Glibenclamide belongs to a family of drugs known as Sulfonylureas. Glucovance is available in the form of a tablet indicated for oral use. It is supplied in three different strengths- Glucovance 250/1.25, 500/2.5, and 500/5. The drug is a prescription medication, so you need to consult your doctor before you buy Glucovance online.

Indications & Dosage of Glucovance

Glucovance is indicated to manage blood sugar levels in patients with type 2 diabetes mellitus. The medication is specifically prescribed when Metformin or Glibenclamide alone are not enough to control blood sugar levels. Glucovance can be also used by a Type 2 diabetes mellitus patient who is taking Metformin and Glibenclamide as separate drugs to control blood sugar levels.

Metformin and Glibenclamide work differently to control blood sugar levels. Metformin reduces the amount of sugar produced by liver and also reduces the absorption of sugar by the body from the diet. The drug also increases sensitivity of insulin receptors that enables the body to use insulin more efficiently. Glibenclamide stimulates the pancreas to make more insulin. It also helps cells respond to insulin in more efficient way.

Your doctor will decide the dose and give specific instructions regarding how to take it. The dose of Glucovance differs with each individual. The usual recommended dose of Glucovance for a patient who has not benefitted from the use of either Metformin or Glibenclamide is one Glucovance 500/2.5, once daily. The usual recommended dose for patients who have been using Metformin and Glibenclamide is one or two Glucovance 500/2.5 daily.

You need to take the recommended dose with a glass of water immediately before your meal. Take the medication at same time every day to get the best effect.

Side Effects & Interactions of Glucovance

Some people may experience less severe side effects such as nausea or vomiting, upper respiratory tract infections, abdominal pain, low blood sugar, diarrhea, or dizziness. If any of these side effects stay for a long time or become bothersome, consult your doctor.

Glucovance may also cause severe side effects such as chest pain, lactic acidosis, high blood sugar, or low blood sugar. Look out for symptoms such as increased thirst, urination or hunger, fatigue, blurred vision, shortness of breath, vomiting, nausea or fatigue, all of which indicate high blood sugar. Some of the symptoms of low blood sugar are shakiness, blurry vision, confusion, sweating, cold sweats, changes in behavior, difficulty speaking, or dizziness. Consult your doctor if you experience any severe side effects after taking a dose of Glucovance.

Glucovance may potentially interact with other drugs you are using and cause side effects. It may interact with medicines such as Cimetidine, Quinine, Isoniazid, Morphine, blood pressure drugs, or Ranitidine.

Before you buy Glucovance, inform the doctor about every medicine you are using, which includes prescription drugs, over the counter medications and herbal supplements.

Warnings & Precautions of Glucovance

You should not buy Glucovance if you are hypersensitive to Glyburide or Metformin. It may not be the right drug for people with certain medical problems such as diabetic ketoacidosis or kidney disease.

Glucovance is listed as a category B pregnancy drug. Nursing mothers, pregnant women, and women planning to start a family should talk to their doctor before using Glucovance.